Research Labs

My lab studies how the retina builds and maintains its synaptic circuitry, focusing on photoreceptor synapses. Using imaging and animal models, we probe how mutations cause inherited blindness and develop AAV gene therapies to restore vision.

My research covers breast cancer and MASLD liver disease: estrogen action and endocrine therapy resistance in breast cancer, and how diet and pollutants like PCBs drive MASLD, using epitranscriptomics, RNA-seq, proteomics, metabolomics and PDX models

We study the intersection of genes and the environment, in particular ethanol. We use the zebrafish as our model system and study the impact of gene-ethanol interactions on tissue morphogenesis and development of the facial skeleton.

Our research examines pathogen within-host dynamics and global molecular epidemiology. Using advanced omics and evolutionary models with human and animal samples, we characterize viral and bacterial evolution to inform health outcomes.

We study immunometabolism and genetics, using Inborn Errors of Metabolism and Immunity to map metabolic programs controlling T cells. Our goal: targeted treatments for IEI/IEM and new immunotherapies for complex immune diseases.

We study epitranscriptomic mechanisms of disease, pairing wet-lab work with bioinformatics to profile m6A modifications, splicing and transcript usage in breast cancer, MASLD, endometriosis and PCOS, uncovering RNA biomarkers and therapeutic targets.

Our lab catalogues genetic diversity in immune receptor genes across humans and animal models, studying how genetic and epigenetic variation shape immune function, disease susceptibility and clinical outcomes.