Biomarker Discovery Through Proteomics and Genomics Research Program
Novel Biomarker Discovery using the latest technologies.
Program Overview
Measurements and main results: Morning urine proteins from 60 children with polysomnographically confirmed OSA and from matched children with primary snoring (n = 30) and control subjects (n = 30) were assessed. A total of 16 proteins that are differentially expressed in OSA were identified and 7 were confirmed by either immunoblots or ELISA. Among the latter, receiver-operator curve analyses of urinary concentrations of uromodulin, urocortin-3, orosomucoid-1 and kallikrein assigned favorable predictive properties to these proteins. Furthermore, combinatorial approaches indicated that the presence of values beyond the calculated cutoff concentrations for three or more of the proteins yielded a sensitivity of 95% and a specificity of 100%.
Conclusions: Proteomic approaches reveal that pediatric OSA is associated with specific and consistent alterations in urinary concentrations of specific protein clusters. Future studies aiming to validate this approach as a screening method of habitually snoring children appears warranted.
Details about our Program
Consideration requires a recently obtained (typically less than three years) doctoral degree from an accredited college in an appropriate field of biological sciences such as Biochemistry, Medicine, Molecular Biology, or Pharmacology.
- Earned doctorate (PhD, MD) or equivalent terminal degree from an accredited institution
- Apply within 3 years from the earned doctorate degree
- US Citizenship or Permanent Residency status or equivalent
- Submit updated CV (Resume) and letter of interest for preliminary evaluation prior to full application
The formal application can be submitted year-round. It must include all of the following documents: Letter of Interest; Curriculum Vitae; Undergraduate and Graduate Transcripts; Three Letters of Recommendation; Status of US Citizenship or Working Visa Required. Please call 502-852-5341 for more information.
