Epigenetics and Biomarkers in Oncology Research Program
A combination of basic and translational science strategies.
Program Overview
Long Interspersed Nuclear Element 1 is the only autonomous mobile DNA capable of self-propagation and is an environmental biomarker that is activated upon an environmental trigger. We have developed an ELISA method to detect and measure Open Reading Frame-1 (ORF1) and have applied it to interrogate serum samples from men with equivocal prostate specific antigen (PSA) results. Polyclonal antibodies were developed using the first 14- amino acid peptide of N-terminal-ORF1 protein. In conclusion, we have developed a competitive ELISA and discovered the presence of iORF1 in serum, which could be used to advance future studies involving ORF1 measurement from blood. In addition iORF1 may be a complement with the PSA screen to better detect prostate cancer.
https://www.sciencedirect.com/science/article/pii/S0009898118305266?via%3Dihub
Details about our Program
Consideration requires a recently obtained (typically less than three years) doctoral degree from an accredited college in an appropriate field of biological sciences such as Biochemistry, Medicine, Molecular Biology, or Pharmacology.
- Earned doctorate (PhD, MD) or equivalent terminal degree from an accredited institution
- Apply within 3 years from the earned doctorate degree
- US Citizenship or Permanent Residency status or equivalent
- Submit updated CV (Resume) and letter of interest for preliminary evaluation prior to full application
The formal application can be submitted year-round. It must include all of the following documents: Letter of Interest; Curriculum Vitae; Undergraduate and Graduate Transcripts; Three Letters of Recommendation; Status of US Citizenship or Working Visa Required. Please call 502-852-5341 for more information.
